AbstractThis article reports to the hazard evaluation studies of a laboratory scale reaction involving 1, 3-diethyl propanedioate and Fuming Nitric acid to form diethyl 2-nitropropanedioate. The process has been optimized and scheduled to the pilot scale batches after process safety evaluation. Fuming Nitric acid addition to 1,3-Diethyl propanedioate at 7°C is highly exothermic reaction with an adiabatic-temperature-rise of 113°C according for RC1e experiment. But the mixture strongly shows an exothermic event at an onset temperature of 60°C to a maximum temperature of 538°C within few seconds with a massive pressure rise in ARC experiment. Indeed, these hazard evaluation experimental results are clear to understand the hazards of the reaction in case of failing in controlled addition, which helped us to redesign the laboratory scale process and notified the required control measures at plant scale.
Daniel A Crowl and Louvar. Chemical process safety: fundamentals with applications, second edition, Prentice hall international series 2009.
Stephen M Rowe. Thermal stability: A review of methods and interpretation of data. Org Process Res Dev 2002; 6: 877-883. http://dx.doi.org/10.1021/op025569u
Franscis Stoessel. Thermal safety of chemical processes: Risk assessment and process design, Wiley-VCH Verlag GmbH and Co 2008.
Yu-Chuan Liang, Can-Yong Jhu, Sheng-Hung Wu, Sun-Ju Shen and Chi-Min Shu. Evaluation of adiabatic runaway reaction of methyl ethyl ketone peroxide by DSC and VSP2. J Therm Anal Calorim 2011; 106: 173-177. http://dx.doi.org/10.1007/s10973-011-1377-0
David J Frurip. Selection of the proper calorimetric test strategy in reactive chemicals hazard evaluation. Org Process Res Dev 2008; 12: 1287-1292. http://dx.doi.org/10.1021/op800121x
Nandi AK, Sutar VB and Bhattacharyya SC. Thermal hazards evaluation for sym-TCB nitration reaction using thermal screening unit (TSu). J Therm Anal Calorim 2004; 76: 895-901. http://dx.doi.org/10.1023/B:JTAN.0000032273.27765.00
Grewer T. Thermal hazards of chemical reactions: New York: Elsevier; 1994; 4.
Fisher HG and Goetz DD. Determination of self-accelerating decomposition temperature using the accelerating rate calorimeter. J Loss Prev Process Ind 1991; 4: 305-16. http://dx.doi.org/10.1016/0950-4230(91)80044-U
Roger Blaine. The search for kinetic reference materials for adiabatic and differential scanning calorimetry. J Therm Anal Calorim 2011; 106: 25-31. http://dx.doi.org/10.1007/s10973-010-1078-0
Gusti JL. Thermal stability screening and reaction calorimetry application to runaway reaction hazard assessment and process safety. J Loss Prev Process Ind 1993; 6: 275-91. http://dx.doi.org/10.1016/S0950-4230(05)80001-4
You ML, Tseng JM and Liu MY. Runaway reaction of lauroyl peroxide with nitric acid by DSC. J Therm Anal Calorim 2010; 102: 535-9. http://dx.doi.org/10.1007/s10973-010-0934-2
Srinivasarao Veedhi, Vikas Mishra, Sunil Kulkarni and Rajasekhar Gorthi. Incident investigation on thermal instability of an intermediate using adiabatic calorimeter. J Therm Anal Calorim 2014; 115: 909-914. http://dx.doi.org/10.1007/s10973-013-3327-5
Miyake A, Kimura A, Ogama T, Satoh Y and Inano M. Thermal hazard analysis of hydrazine and nitric acid mixtures. J Therm Anal Calorim 2005; 80: 515-518. http://dx.doi.org/10.1007/s10973-005-0686-6
Wang QS, Rogers WJ and Mannan MS. Thermal risk assessment and rankings for reaction hazards in process safety. J Therm Anal Calorim 2009; 98: 225-33. http://dx.doi.org/10.1007/s10973-009-0135-z
Srinivasarao Veedhi and Anil Sawant. Designing a safer process for the reaction of TFA with sodium borohydride in THF by calorimetric technique. J Therm Anal Calorim 2013; 111: 1093-1097. http://dx.doi.org/10.1007/s10973-012-2514-0
Chervina S, Evon SE and Bodman GT. Assessing thermal hazards of reaction mixtures. J Therm Anal Calorim 1997; 49: 1635-1645. http://dx.doi.org/10.1007/BF01983724
Logvinenko V, Drebushchak V, Pinakov D and Chekhova G. Thermodynamic and kinetic stability of inclusion compounds under heating. J Therm Anal Calorim 2007; 90: 23-30. http://dx.doi.org/10.1007/s10973-007-8473-1
Howell BA and Carter KE. Thermal stability of phosphinated diethyl tartrate. J Therm Anal Calorim 2010; 102: 493-498. http://dx.doi.org/10.1007/s10973-010-0875-9
Han X, Sun YL, Wang TF, Lin ZK, Li SF, Zhao FQ, et al. Thermal decomposition of ammonium perchlorate based mixture with fullerenes. J Therm Anal Calorim 2008; 91(2): 551-7. http://dx.doi.org/10.1007/s10973-007-8290-6
John Atherton and Frederic Gil. Incidents that define process safety, A joint publication of the center for chemical process safety of the American institute of chemical engineers and John Wiley and Sons, Inc 2008.
Arslan H, Kulcu N and Pekacar AI. Thermal decomposition kinetics of anilino-p-chlorophenylglyoxime complexes of cobalt (II), nickel (II) and copper (II). Turk J Chem 2003; 27: 55-61.
Kissinger HE. Reaction kinetics in differential thermal analysis. Anal Chem 1957; 29: 1702-6. http://dx.doi.org/10.1021/ac60131a045
Dao-Xing Sun, Xiao Miao, Chuan-Xin Xie, Jing Gu and Rong Li. Study on thermal properties and kinetics of benzoyl peroxide by ARC and C80 methods. J Therm Anal Calorim 2012; 107: 943-948. http://dx.doi.org/10.1007/s10973-011-1536-3
Abduljelil Iliyas, Kelly Hawboldt and Faisal Khan. Kinetics and safety analysis of sulfide mineral self-heating. J Therm Anal Calorim 2011; 106: 53-61. http://dx.doi.org/10.1007/s10973-011-1621-7